The expression "safe hypertension" has been utilized since the mid 1960's to distinguish patients with hard to-treat hypertension, meaning generally, protection from pharmacologic therapy. In the fifty years since the term was apparently first applied, safe hypertension has been reliably characterized as inability to control hypertension notwithstanding of purpose of at least 3 antihypertensive specialists of various classes, including a diuretic. The 2008 American Heart Association Scientific Statement on safe hypertension remembered for its definition patients whose pulse had been uncontrolled with 3 prescriptions, yet controlled with at least 4 medications. While the quantity of meds expected to fulfill the definition is erratic, the reason for making a classification of safe hypertension is to recognize patients who, in light of the trouble in controlling their circulatory strain, may profit from extraordinary symptomatic and remedial contemplations, including reference to a hypertension subject matter expert. Having a settled upon definition that can be dependably applied to various associates has likewise worked with research for this subgroup of patients, including recognizable proof of hazard factors and basic instruments, evaluating results and creating designated medicines.