The COVID-19 pandemic has reappeared in subsequent waves in the form of more transmissible and potentially more virulent variants.PM2.5 This increase in COVID-19 incidence has been attributed to the reversal of regional lockdowns and measures, endorsing physical distancing which were legally enforced in most countries. Following lockdown, a contemporaneous reduction in COVID-19 rates and atmospheric pollution including particulate matter (PM2.5) were noted only to be partially reversed once lockdown was ceased. This reversal of lockdown also involved a recrudescence of elevated levels of the pollutant particulate matter PM2. It has been suggested that particulate matter PM2.5 was not only responsible for SARS-CoV-2 transmission, but may also have been involved in this virus’ evolution. Acting as a SARS-CoV-2 vector, PM2.5 may have been responsible for exerting selective pressure determining the emergence of the first variant called the G614 variant.