The incidence of systemic microbial infections has been increased severely due to increased of immune compromised hosts. Also, the increasing predominance of microbial resistance to huge antibiotic is becoming foremost apprehension. Consequently, the expensive treatment, toxicities and drug resistance pose new conundrum insisting constant renewed efforts in the development of new classes of antimicrobial with more specific action.1,2,4-Triazoles have attracted considerable attention in the fields of medicine and agrochemical research as well as in materials science, due to their unique structures and properties. 1,2,4-Triazole and its derivatives belong to a class of exceptionally active compounds possessing many pharmacological properties.1,2,4-Triazole and its derivatives are an important class of compounds which possess diverse agricultural, industrial and biological activities including anti-microbial Palekar et al.sedative anticonvulsant Li et al