Related m-RNA vaccine it is relevant to observe that they were introduced in rapid way to fight COVID-19 spread. This first received by health authorities emergency approval, and then complete approval by FDA on December 18, 2020. The time under clinical evaluation was shorter then classic vaccine required. The mechanism involved in this new products imply a trasduction of the genetic code of the m-RNA used to produce SPIKE protein by human ribosome. But as showed by some in vitro study by Markus Alden is the first in vitro study on the effect of COVID-19 mRNA vaccine BNT162b2 on human liver cell line [1]. The present evidence on fast entry of BNT162b2 into the cells and subsequent intracellular reverse transcription of BNT162b2 mRNA into DNA”. This research was performed at 6-24-48 hours and the result shows this effect during this period