A 55 year old female patient, born in the Middle east and living in North America since the age of 12, has been suffering from multiple complex medical disorders. These include history of seronegative Juvenile Rheumatoid Arthritis (JRA), Raynaud Phenomenon, Ulcerative Colitis (UC), severe Endometriosis with multiple excisions and ablation of endometriotic lesions and total abdominal hysterectomy with a Bilateral Salpingo- Oophorectomy (TVH/BSO), Gastroesophageal Reflux Disease (GERD), episodes of Interstitial Cystitis (IC), history of dysequilibrium and vertigo diagnosed as Vestibular Migraine and Persistent Postural-Perceptual Dizziness (PPPD), Hashimoto thyroiditis, fibromyalgia, migratory polyarthropathy, and kidney disease. The patient was treated with a trial of Janus Kinase 2 (JAK2) inhibitor. She responded well to the treatment and has seen significant improvement in her complex GastroIntestinal (GI), neurological, rheumatological, urogenital, kidney and thyroid clinical manifestations. This is a strong indication that many, if not all, of the patient’s medical manifestations had an underlying immunological origin.