Cissus populnea belongs to the Vitaceae family, a grape family of angiosperm with about 14 genera and 900 species principally distributed in tropical regions, with a few genera in temperate regions . C. populnea is very little known in Cameroon and not well documented. However, it is an important medicinal plant in Nigeria where it is very famous for its uses in traditional medicine as well as like a spice. The plant is cited in the treatment of several infectious diseases including male infertility, urinary infections, skin diseases, indigestion, wounds, venereal diseases, gonorrhoea, ulcers, jaundice, icterus, trypanosomiasis. C. populnea is also used against inflammations, colics, hypertension, hemorrhoids, fever, oedema, yellow fever, leprosy , malaria . The roots of the plant are used in Adamawa region of Cameroon for the treatment of breast cancer.